Hydroxychloroquine 400 Tablet

What is Hydroxychloroquine 400 mg

Hydroxychloroquine 400 mg is a medicine recommended by doctors to treat Rheumatoid Arthritis, Systemic lupus erythematosus (SLE), Diabetes Mellitus (Type 2), and Malaria. It includes Hydroxychloroquine Sulfate as the active component, a substance, and is developed to provide Immunomodulatory and antimalarial effects at 400 mg potency. It is produced by Kachhela Medex Pvt. Ltd. and is globally reliable in the management of autoimmune and parasitic diseases.

Hydroxychloroquine 400 mg Tablet Uses

Rheumatoid arthritis

Hydroxychloroquine 400 mg for rheumatoid arthritis treats a persistent autoimmune disorder, acting on joints and hindering body movement as the key symptoms. The drug is applied when it is necessary to reduce pain, stiffness, swelling, and inflammation.

Systemic lupus erythematosus

In the case of SLE, Hydroxychloroquine 400 mg aids in the prevention of flare-ups and organ damage, reduces fatigue and rash, joint pain, and leads to the remission and control of the disease.

Type 2 diabetes mellitus

This off-label tablet is applied in Type 2 Diabetes as an insulin sensitizer. It leads to better glycemic control, stimulating the receptors of insulin and lowering blood sugar.

Malaria

Hydroxychloroquine 400 mg is an antimalarial drug applied in the prevention and treatment of some schizophrenic malaria, most specifically in areas where the malaria-carrying parasite, Plasmodium falciparum, is not immune to the effect of chloroquine-type medications.

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How to Take Hydroxychloroquine 400 mg

Take the Tablet Hydroxychloroquine 400 mg orally with food or milk to lessen stomach upset. Take the tablet whole with a glass of water and do not crush or chew. Make sure that you keep a regular evening routine, and it should be at a particular time.

The dosage can be given depending on the condition you are in, your weight, as well as your doctor's prescription.

Eye examination and blood tests are advisable frequently, where the treatment is very long-term. Never miss or suddenly discontinue taking this medication without first talking to your medical doctor.

How does it work in the body

Rheumatoid arthritis

The activity of the immune system is modified by hydroxychloroquine as it suppresses the effect of toll-like receptors and decreases the level of production of cytokines that cause inflammation. It retards disease progression, stops inflammation, and damages joints.

Systemic lupus erythematosus

Hydroxychloroquine 400 mg tablet balances immune hyperactivity and also lowers the production of autoantibodies in SLE. Such a drug enhances the skin's sensitivity towards sunlight, prevents blood clots, and facilitates various systemic complications.

Type 2 diabetes mellitus

Hydroxychloroquine 400mg works by enhancing insulin receptor sensitivity, lowering the liver's glucose production, and stimulating peripheral glucose uptake, consequently improving the control of glycemia in insulin-resistant persons.

Malaria

Being an antimalarial, it disrupts the digestion mechanism of the parasite that causes red cells to accumulate toxic heme and kills the parasite by inhibiting the activity of heme polymerase.

Benefits of Hydroxychloroquine 400 mg

Physical benefits

• Minimizes persistent joint edema and inflammation
• Reduces the incidence of skin rashes and lupus flare-ups
• Helps diabetic people better control their blood sugar levels.
• Prevents and cures particular forms of malaria
• Increases vitality and lessens exhaustion
• Increases the mobility of muscles and joints
• Lowers the risk of organ damage in lupus patients
• Reduces Type 2 diabetes insulin resistance

Psychological benefits

• Reduces the emotional strain brought on by persistent pain
• Aids patients in regaining self-assurance in day-to-day activities
• Reduces flare unpredictability, which fosters mental calm
• Lessens anxiety brought on by blood sugar changes
• Improves sleep quality by managing pain
• Promotes regular wellness practices
• Enhances general mental toughness in chronic illnesses
• Encourages patient faith in a consistent

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Hydroxychloroquine 400 mg Dosage

• Rheumatoid Arthritis: Normally 400 mg daily in a single dose, but changed according to the weight of the patient and their reaction.
• SLE: An average dose is 200-400mg per day relative to disease severity.
• Type 2 Diabetes Mellitus: Off-label doses are between 200–400 mg per day, with strict supervision by the physician.
• Malaria: An initial dose of 800 mg, followed by 400 mg at 6 h, 24 h, and 48 h after the first dose.
• Malaria prophylaxis: Normally 400 mg per week, beginning 2 weeks ahead of exposure, and continuing 4 weeks after.

It is essential to adjust dosages; never disregard instructions left by your doctor.

Side Effects of Hydroxychloroquine 400 mg

Hydroxychloroquine 400 mg is generally tolerated well, and, as with any medicine, may also result in side effects. These are mostly minor and controllable.

The majority of side effects involve:

• Headache
• Vomiting or indigestion
• Diarrhea
• Dizziness
• Lack of appetite
• Itching or rash of the skin
• Mood changes
• Visual problems

It is necessary to report the side effects as soon as possible and carry out regular medical examinations to prevent long-term complications.

Warnings and Precautions

• If you already have macular or retinal damage, do not use.
• Regular eye exams every six to twelve months are necessary for long-term use.
• When used by people who have heart rhythm abnormalities (QT prolongation), use caution.
• Because of the possibility of hemolysis, it is not recommended for those who are G6PD deficient.
• Be cautious if you have liver or kidney disease; you may need to change your dosage.
• If you are pregnant, nursing, or intend to become pregnant, let your doctor know.
• Avoid combining without supervision with medicines or alcohol that alter blood sugar levels.
• Tablets should be stored at room temperature, out of direct sunlight and moisture.
• Keep out of children's reach and in a cool, dry location away from the sunlight.

Drug Interactions

Hydroxychloroquine 400 mg has the propensity to react with an array of drugs, and ought to be utilized with caution:

• Digoxin: Raises serum concentration and the possibility of poisoning.
• Insulin or oral antidiabetics: Can produce low blood sugar.
• Antacids: decrease the absorption of Hydroxychloroquine; minimum separation is 4 hours.
• Tamoxifen: Might lead to retinal damage.
• Drugs that increase QT interval, e.g., azithromycin, amiodarone: May increase cardiac risks.
• Cimetidine: Prevents metabolism and causes blood elevation

Never fail to inform your physician about any medications or supplements before the administration of this drug

Conclusion

Hydroxychloroquine 400 mg Tablets are trusted, general medications suitable for the treatment of various chronic ailments and parasitic ailments, which include Rheumatoid Arthritis, SLE, Type 2 Diabetes Mellitus, and Malaria.

It aids in the management of inflammation, immune equilibrium, and has glycemic functions and antimalarial assistance. Its long-term use can be very relieving and enhance the quality of life with regular surveillance.

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