What is Imatinib 400 mg Tablet?
Imatinib 400mg Tablet is an anti-cancer drug that is prescribed as treatment for GIST (gastrointestinal stromal tumors) and CML (chronic myeloid leukemia). It has an active pharmaceutical ingredient (API) of imatinib, which is a selective tyrosine kinase inhibitor, and it blocks selectively those proteins involved in the growth and proliferation of the cancerous cells. Developed by the American Remedies Pvt. Ltd.
Imatinib 400 mg Uses
The drug Imatinib 400 is mostly employed in the treatment of blood cancer and chronic myeloid leukemia, whereby it has been applied in the treatment of the BCR-ABL fusion product that is seen in abnormal cell proliferation. It is also effective in gastrointestinal stromal tumors and cancers of the digestive tract lining that are rare.
In addition, it is also used in their treatment, and they include dermatofibrosarcoma protuberans and some bone marrow illnesses. It's special therapy halts the progression of cancerous cells, downsizes cancerous tumors, prevents the proliferation of the disease, and improves chances of survival.
How to Take It?
Patients should be instructed to take Imatinib 400 mg Tablet with a glass of water and should swallow it whole. It is indicated that it ought to be consumed at mealtimes to avoid an upset stomach, and also at the same time, when the therapeutic impact will be optimal. Follow the instructions of the healthcare providers to the letter to minimize the side effects and make the most out of it.
How Does Imatinib 400 mg Work?
Imatinib 400 tablet is a tyrosine kinase inhibitor (TKI) that has the capacity to impede some altered enzymes, specifically BCR-ABL, which is a protein tyrosine kinase made by mutated genes in harmful cells.
Suppression of these key signaling molecules with the take up of Imatinib 400 mg prevents proliferation of the cancer cells and programmed cell death (apoptosis) of the cancer cells. It binds to the malfunctioning BCR-ABL protein that is unique to the cancerous cells and is active signaling and growth of the cancerous cells in CML.
In gastrointestinal stromal tumors, it kills the defective proteins KIT or PDGFR that give rise to the tumor. Such a preference ability of inhibition disturbs the growth of the cancer without killing the normal cells, thereby balancing the toxicity and increasing the efficacy of the therapy.
Effectiveness and Clinical Benefits
Imatinib 400mg has significantly improved the treatment outcomes for patients with CML as well as GIST. It increases life considerably, induces remission, and enhances markers of the quality of life on the basis of clinical trials as well as real-life findings.
The characteristic feature of chronic myeloid leukemia is the implementation of long-term molecular responses in case of continuous application of the dosage 400 mg daily, leading to a delay in the development of the disease. It controls the development of the tumor in intestinal stromal tumors, and it decreases the mass of the lesion, especially the inoperable or metastatic lesions. The patients will have better control over the disease, less hospitalization, and the ability to lead full lives.
Dosage
The usual therapeutic dose of the drug in an adult is a 400 mg single-dose tablet. In order to minimize the gastrointestinal side effects, the tablet Imatinib 400 mg is to be administered regularly with food.
Their doses may require adjustment in patients who have dysfunction of liver or kidney, secondary effects, or problems co-morbidity. Medical observation will be undertaken on a periodic basis to monitor efficacy and adjustment of the doses. The missed doses can be taken when one remembers, unless it happens to be near the next dose, then one is not to take the double doses.
Imatinib 400 mg Side Effects
- Edema
- Diarrhea
- Nausea
- Vomiting
- Fatigue and weakness
- Rash
- Abdominal pain
- Muscle cramps
- Weight gain
- Dizziness
- Headache
Where to Buy Imatinib 400 mg Tablet?
You can Buy Imatinib 400 mg from licensed pharmacies like malaysiameds.com in Malaysia. To make it more convenient and accessible, some patients choose to buy Imatinib 400 mg Buy Online, on credible medical sources that guarantee authenticity and safe distribution. Even though alternatives in the form of brand-name substitutes are available, affordable versions of the drug are widely available as Generic Imatinib 400 mg.
Warnings and Precautions
Warnings
- It is not supposed to be used in breastfeeding mothers, unless a doctor advises.
- Never discontinue medication without consulting your health professional first, as this may result in the relapse of the disease.
- Tell your physician your past medical history that was referred to as liver or kidney, or heart disease.
Precautions
- Regular blood tests must be conducted to monitor blood count and liver and kidney functions during treatment.
- Grapefruit or grapefruit juice should also be avoided since they will affect the drug metabolism.
- The patients should be instructed to notify about the symptoms of infection, bleeding, or unusual fatigue.
- Avoid drinking alcohol in the course of treatment or consult the doctor.
Drug Interactions
Imatinib 400 mg can interact with:
- Phenytoin
- CYP3A4 inhibitors and inducers
- Warfarin and other anticoagulants
- Cyclosporine
- Carbamazepine
- Clarithromycin
Conclusion
The Imatinib 400 mg Tablet is a mandatory targeted therapy for chronic myeloid leukemia and gastrointestinal stromal tumors. Its selective inhibition capability of the enzymes that drive cancer has significantly enhanced the outcome of patients by preventing cancer growth and allowing the disease to be controlled over a long period of time. Its manageable safety profile and effectiveness make it a staple treatment in current oncology with proper utilization under medical supervision.
FAQs
Can Imatinib 400 mg be taken during pregnancy?
The use of imatinib during pregnancy is not suggested due to the harm that it may produce on the unborn baby. The best thing to do is to talk to your doctor to receive individual advice.
Can I stop taking Imatinib 400 mg if I feel better?
No. Quitting or discontinuing the use of imatinib without the advice of a healthcare expert may cause relapse of the ailment. Use the treatment not as long as recommended by the physician.
What should I do if I miss a dose?
In case you miss one or more doses, then it would be better to take them as soon as you remember. But then take not so soon the next dose. You do not have to mix the two doses.
Is Imatinib 400 mg a chemotherapy drug?
Imatinib is the targeted therapy, or rather a tyrosine kinase inhibitor, as compared to conventional chemotherapy, which lacks the specificity of any cancer cells.
What foods should you avoid when taking Imatinib 400 mg?
Avoid the consumption of grapefruit and grapefruit juice at all times, as it can alter the absorption levels of the drug and the effect it has on a person.
Leave A Review